For questions like these, you can use the calculator on this site by going to the top of the page and clicking the "Home" tab, but I'll help you out here.
First, follow PEMDAS (Parenthases, Exponents, Division/Multiplication, Addition/Subtraction)
This first step in this equation is 2000*4000, as this is multiplication, which comes before subtraction. 2000*4000=8,000,000 (8 million).
Next, do subtraction. 8,000,000-60,000,000,000=-59,992,000,000.
In conclusion, 2000*4000-60000000000=-59992000000.