5^8*(-3)^8
PEMDAS = (Parentheses and Exponents), then (Multiplication and Division), then (Addition and Subtraction).
5^8 = 5*5*5*5*5*5*5*5 = 390625
-3^8 = (-3)*(-3)*(-3)*(-3)*(-3)*(-3)*(-3)*(-3) = -6561
390625*(-6561) = -2562890625