We have the number of possible hands that include no queens or one queen.
For the number that include no queens, we want to select 5 cards from any of 12 ranks, not including the queens. So we have C(48,5) =1,712,304
For the number that include one queen, and no more, we want to choose 1 of the 4 queens and then any 4 cards from the other 48. So we have C(4,1)*C(48,4) = 778,320
And adding these together, we get, 2,490,624
We have the number of possible hands that include no queens or one queen.
For the number that include no queens, we want to select 5 cards from any of 12 ranks, not including the queens. So we have C(48,5) =1,712,304
For the number that include one queen, and no more, we want to choose 1 of the 4 queens and then any 4 cards from the other 48. So we have C(4,1)*C(48,4) = 778,320
And adding these together, we get, 2,490,624