The exclamation mark is the factorial sign. So 21!, spoken as twenty-one factorial, means 21*20*19*...*3*2*1,
21!5!6!10!=21∗20∗19∗...∗11∗10∗9∗...∗2∗15!∗6!∗10∗9∗...∗2∗1=21∗20∗...∗115∗4∗...∗2∗1∗6∗5∗...∗2∗1=14079294028800120∗720=1407929402880086400=162954792
.