The expression \((2x-9)(x+8)\) can be simplified by using the distributive property (FOIL method):
\[(2x-9)(x+8) = 2x(x) + 2x(8) - 9(x) - 9(8).\]
Simplify each term:
\[2x^2 + 16x + 9x - 72.\]
Combine like terms:
\[2x^2 + 25x - 72.\]
So, the simplified expression is \(2x^2 + 25x - 72\).