1 0 1 1 0 1 = 45
32 8 4 1
137 = 0001 0011 0111 = 256 +32 + 16 + 4 + 2 + 1 = 311
b21 = 1011 0010 0001 = 2048 + 512 + 256 + 32 +1 = 2849
When subtracting a larger number from a smaller number, change it to B-A and change the sign of the result
I'll use the complement method to subtract them: Take the inverse of A and add 1 then add them and change the sign
1110 1100 1001
1011 0010 0001
1 1001 1110 1010 = -( 2048 +256 +128 + 64 + 32 + 8 + 2) = -2538