I like to separate these into parentheses to make it easier to solve
(3x2y) - (2xy2) + (10xy) - (15y) for x= -5, y=3
(3[-5]2[3]) - (2[-5][3]2) + (10[-5][3]) - (15[3])
(3[25][3]) - (2[-5][9]) + ([-50][3]) - (15[3])
(225) - (90) + (-150) - (45)
(135) + (-195) = 60
So, if I did everything correctly, the answer is 60.